Neurology
Every neural-interface program spends to keep its signal stable over years. But 'drift' is two opposite failures with opposite solutions — and a dollar is mis-spent until you know which one you're looking at.
Long-Term BCI/BSI Stability
- DOSSIER70–90 pp · 31 figures. Keystone: SIROF electrodes record at twice the platinum rate despite worse physical degradation.
- WORKBOOK20 sheets. 85 claims with verbatim excerpts; device-material/failure-mode/regulatory trackers.
- AUDITRelease-ready. Honest base: rodent-heavy, sub-6-month, zero direct human-chronic evidence.
- HYPOTHESES14 falsifiable, dated, each connecting ≥2 decay layers.
Exactly what's inside Long-Term BCI/BSI Stability.
The full research-report table of contents and every one of the 20 tables in the evidence workbook — the real structure of what you license, not a teaser.
- Executive Summary
- Scope and Evidence Integrity
- Decision Snapshot Overview
- Buyer Decision Cheat Sheet
- Source Quality Dashboard
- Fidelity Decay Model
- Current Signal Update 2025 2026
- Cross Layer Convergence Map
- Evidence Maturity and Intervention Matrix
- Competitive and Asset Landscape
- Key Findings
- Quantitative Evidence
- Key Findings Quant Synthesis
- Mechanistic Deep Dive
- Safety Failure Modes
- Materials Manufacturing Feasibility
- Non Obvious Early Opportunities
- Prioritized Hypotheses
- Most Valuable Next Studies
- Validation Falsification Gates
- Regulatory Evidence Standards
- Ethical Access Societal
- Commercial Adoption Market
- Strategic Recommendations
- Limitations
- Final Judgment
- Expert Review and Validation
- Appendix Methodology Glossary
- References
Workbook Guide
An orientation to the workbook — its scope, how the claim counts reconcile, and the audit posture.
In this dossier: scope, reconciliation, and audit posture
Claim Ledger
Every factual claim in the report, independently re-verified against its primary source, each carrying a support verdict and a recalibrated evidence grade.
In this dossier: 84 customer-facing claims (analyst-verified; maturity-tagged). 'species (auto-tag, broad)' over-counts human mentions; 'primary_subject (adjudicated)' is the defensible…
Evidence Table
The full registry of cited sources — PMIDs, NCTs and DOIs — with metadata, resolved live against the primary record.
In this dossier: design, population, and results per kept claim
Source-Support Verdicts
The verbatim source excerpt behind each claim, with an independent verdict on whether the source actually supports it.
In this dossier: Independent source-support verdicts (full-text re-verification; 0 retractions)
Source Quality Summary
A reconciled view of source quality across the evidence base, with the grading rationale.
In this dossier: Source Quality Dashboard (reconciled; maturity axes)
Intervention Scorecard
Programs or modalities scored on the framework's axes — a structured, side-by-side comparison (expert, ordinal, non-evidentiary).
In this dossier: Intervention x decay-layer scorecard (expert ordinal 0-3; NON-EVIDENTIARY)
Layer Scorecard
Programs or modalities scored on the framework's axes — a structured, side-by-side comparison (expert, ordinal, non-evidentiary).
In this dossier: Fidelity-Decay-layer scorecard (expert ordinal; NON-EVIDENTIARY)
Device-Material Tracker
A structured tracker of the programs, signals and evidence in this dimension of the analysis.
In this dossier: Device / material / coating tracker
Asset-Sponsor Tracker
Who is developing what — assets, sponsors and platforms, with the reporting basis made explicit.
In this dossier: Asset / sponsor / platform tracker (reporting basis explicit; designation is not approval)
Trial-Catalyst Tracker
A dated calendar of trials and readouts — sponsor, phase, indication, and the catalyst that moves the thesis.
In this dossier: Trial / registry & catalyst tracker (reporting basis explicit)
Failure-Mode Tracker
A structured tracker of the programs, signals and evidence in this dimension of the analysis.
In this dossier: Failure-mode & reliability tracker
Biomarker-Endpoint Map
How candidate biomarkers map to clinical endpoints — the bridge from a measurement to an outcome.
In this dossier: Biomarker-to-endpoint bridge map
Regulatory Tracker
Regulatory designations and pathways relevant to each program — noting that a designation is never an approval.
In this dossier: Regulatory tracker (Breakthrough / IDE / 510(k) / PMA; reporting basis explicit; designation != approval)
Figure Source Map
The provenance of every figure — its underlying data and how it was produced.
In this dossier: Figure source map (31 figures; lineage)
Figure Attempt Ledger
The provenance of every figure — its underlying data and how it was produced.
In this dossier: Figure attempt ledger (NONE PENDING; 21 deterministic + 10 generative)
Hypotheses Ledger
The forward-looking, falsifiable hypotheses — each with a predicted readout and an explicit disconfirming test.
In this dossier: Hypotheses ledger (14; non-obvious, falsifiable, current)
Most Valuable Next Studies
The highest-leverage experiments to run next, prioritized — a ready-made research agenda.
In this dossier: Most valuable next studies (de-risking experiments, 2026-2028)
Verification-Search Log
A dated log of the verification searches run — the audit trail behind the evidence.
In this dossier: Verification & search log (all queries; date window 2025-2026)
Excluded Claims
Every claim we considered and removed, with the reason — showing the work, including what didn't make the cut.
In this dossier: Excluded-claim dispositions (all 80). RECOVER=17 high-value cross-field (6 cited in narrative + 11 retained in trackers/registry); APPENDIX_TRACKER=33…
Salvage Ledger
Claims recovered from the excluded set after deeper verification.
In this dossier: Salvage ledger (reuse / improve / replace / fix / build)
Click any table to see what it is.
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Click a buyer to see exactly what they get.
Every claim resolves to a primary source.
This dossier ships with its independent diligence audit. Evidence is labelled Established / Inferred / Hypothesis. A surrogate is never equated with outcome; a designation is never an approval.
Zemi Research publishes independent, pre-packaged research reports delivered as digital downloads (PDF + spreadsheet). These are information products — not medical, clinical, investment, legal, or professional advice; not a consulting, advisory, or regulated service; and they create no professional-client relationship. Provided for general informational use by industry professionals.