Infectious Disease
Precision AMR countermeasures don't fail for lack of killing power. They fail because the pathogen evolves out from under them — and almost every program spends its most expensive budget fighting that evolution in the one place it cannot win.
Precision AMR Countermeasures
- DOSSIER77 pp · 31 figures. The Resistance-Cornering Stack and the escapable-vs-cornered law applied to every intervention.
- WORKBOOK22 sheets. A 31-trial dated catalyst tracker, scored landscape, 90 claims, full search log.
- AUDIT92.4 / 100, release-ready. 138 sources resolved live, zero retractions.
- HYPOTHESES12 falsifiable, dated. Honest: an early, largely preclinical base — zero direct evidence for the integrated system.
Exactly what's inside Precision AMR Countermeasures.
The full research-report table of contents and every one of the 22 tables in the evidence workbook — the real structure of what you license, not a teaser.
- Executive Summary
- Scope and Evidence Integrity
- Decision Snapshot Overview
- Buyer Decision Cheat Sheet
- Source Quality Dashboard
- Resistance Cornering Model
- Current Signal Update 2025 2026
- Cross Layer Convergence Map
- Evidence Maturity and Countermeasure Matrix
- Competitive and Asset Landscape
- Key Findings
- Quantitative Evidence
- Key Findings Quant Synthesis
- Mechanistic Deep Dive
- Safety Failure Modes
- Manufacturing Cmc Feasibility
- Non Obvious Early Opportunities
- Prioritized Hypotheses
- Most Valuable Next Studies
- Validation Falsification Gates
- Regulatory Evidence Standards
- Ethical Access Societal
- Commercial Adoption Market
- Strategic Recommendations
- Limitations
- Final Judgment
- Expert Review and Validation
- Appendix Methodology Glossary
- References
Workbook Guide
An orientation to the workbook — its scope, how the claim counts reconcile, and the audit posture.
In this dossier: scope, reconciliation, and audit posture
Claim Ledger
Every factual claim in the report, independently re-verified against its primary source, each carrying a support verdict and a recalibrated evidence grade.
In this dossier: 89 audited kept claims (independently verified; AMR-axis tagged; value-based grades). 86 customer-facing after de-dup: see 'merged_into' (K013->K023, K089->K014…
Source-Support Verdicts
The verbatim source excerpt behind each claim, with an independent verdict on whether the source actually supports it.
In this dossier: Independent source-support verdicts (full-text/abstract re-verification; 0 retractions; verbatim excerpts)
Evidence Table
The full registry of cited sources — PMIDs, NCTs and DOIs — with metadata, resolved live against the primary record.
In this dossier: all independently re-verified sources (138 PMID + 22 DOI + 30 NCT; 0 retracted)
Source Quality Summary
A reconciled view of source quality across the evidence base, with the grading rationale.
In this dossier: Source Quality Dashboard (reconciled; recalibrated; zero-direct anchor)
Countermeasure Scorecard
Programs or modalities scored on the framework's axes — a structured, side-by-side comparison (expert, ordinal, non-evidentiary).
In this dossier: Countermeasure x cornering scorecard (expert ordinal 0-4; NON-EVIDENTIARY)
Cornering-Layer Scorecard
Programs or modalities scored on the framework's axes — a structured, side-by-side comparison (expert, ordinal, non-evidentiary).
In this dossier: Cornering-layer scorecard (expert synthesis; non-evidentiary)
Pathogen Strategy Tracker
A structured tracker of the programs, signals and evidence in this dimension of the analysis.
In this dossier: Pathogen strategy tracker (cornering lever differs by pathogen/clone)
Asset-Sponsor Tracker
Who is developing what — assets, sponsors and platforms, with the reporting basis made explicit.
In this dossier: Asset / sponsor / platform tracker (reporting basis explicit; designation != approval)
Trial-Catalyst Tracker
A dated calendar of trials and readouts — sponsor, phase, indication, and the catalyst that moves the thesis.
In this dossier: Trial / registry & catalyst tracker (ClinicalTrials.gov v2; status as of June 2026)
Resistance-Escape Tracker
A structured tracker of the programs, signals and evidence in this dimension of the analysis.
In this dossier: Resistance-escape & defense-system tracker (collateral effects + anti-phage defenses)
Diagnostic Performance Tracker
A structured tracker of the programs, signals and evidence in this dimension of the analysis.
In this dossier: Diagnostic performance tracker (analytical-validation; AUROC != clinical utility)
Microbiome Tracker
A structured tracker of the programs, signals and evidence in this dimension of the analysis.
In this dossier: Microbiome / colonization-resistance tracker (safety pillar)
Biomarker-Endpoint Map
How candidate biomarkers map to clinical endpoints — the bridge from a measurement to an outcome.
In this dossier: Biomarker-to-endpoint bridge map
Regulatory Tracker
Regulatory designations and pathways relevant to each program — noting that a designation is never an approval.
In this dossier: Regulatory tracker (channel named; designation != approval)
Figure Source Map
The provenance of every figure — its underlying data and how it was produced.
In this dossier: Figure source map (31 figures; full lineage)
Figure Attempt Ledger
The provenance of every figure — its underlying data and how it was produced.
In this dossier: Figure attempt ledger (31; NONE PENDING; 19 deterministic + 12 generative)
Hypotheses Ledger
The forward-looking, falsifiable hypotheses — each with a predicted readout and an explicit disconfirming test.
In this dossier: Hypotheses ledger (12; non-obvious, falsifiable, current; each couples >=2 layers)
Most Valuable Next Studies
The highest-leverage experiments to run next, prioritized — a ready-made research agenda.
In this dossier: Most valuable next studies (de-risking experiments, 2026-2028)
Verification-Search Log
A dated log of the verification searches run — the audit trail behind the evidence.
In this dossier: Verification & search log (independent re-verification + latest-developments sweep; 62 logged queries)
Excluded Claims
Every claim we considered and removed, with the reason — showing the work, including what didn't make the cut.
In this dossier: Excluded-claim dispositions (all 79). RECOVER=13 high-value adjacent; APPENDIX_TRACKER=43 verified/context; EXCLUDE=23 (10 dup + 5 structural + off-frame).
Salvage Ledger
Claims recovered from the excluded set after deeper verification.
In this dossier: Salvage ledger (reuse / sharpen / fix / recover / add)
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Every claim resolves to a primary source.
This dossier ships with its independent diligence audit. Evidence is labelled Established / Inferred / Hypothesis. A surrogate is never equated with outcome; a designation is never an approval.
Zemi Research publishes independent, pre-packaged research reports delivered as digital downloads (PDF + spreadsheet). These are information products — not medical, clinical, investment, legal, or professional advice; not a consulting, advisory, or regulated service; and they create no professional-client relationship. Provided for general informational use by industry professionals.