Frontier Medical Research Dossiers

Frontier medical evidence moves faster than any team can read it. We turn it into decision-grade dossiers you can buy today.

Each Zemi dossier pairs a ~100-page decision report with its real engine: a 30-to-45-sheet Evidence & Decision Workbook you operate — a live power-calculation engine, an executable classifier, a full source-audit trail, and 13+ falsifiable, pre-powered hypotheses — built from hundreds of verified sources.

Built for / Pharma / Biotech / Venture / Translational teams
24dossiers · 9 domains
100+verified sources each
0retractions
2published preprints
How to get one

One price. Everything included. Two ways in.

Buy a dossier
$3,500 $5,500

Full report + live workbook, instant download

The complete PDF research report and the Evidence & Decision Workbook with live, editable power calculations. Single-license, secure Stripe checkout.

Not sure which fits?

Tell us your program or thesis

Describe your indication, target, or diligence question and we'll point you to the right dossier — or scope a custom one in a domain we haven't published yet.

See what's possible

From dossier to clinical trial

See a single dossier hypothesis carried all the way to a full clinical trial design — the worked fibrosis example, published in full.

Inside every dossier · the real engine

The Evidence & Decision Workbook — 30 to 45 live sheets you operate, not just read.

The report makes the argument; the workbook is where the value lives — an auditable evidence system plus two working tools, in one spreadsheet you drive with your own numbers. It is included with every dossier, and it is the most valuable thing in the package.

Live power engine

Power Calculations you re-run

Every hypothesis rendered as live NORM.S.INV sample-size formulas with per-effect sensitivity bands and a cached-vs-live integrity check. Change the effect, control rate, or alpha and every required n recomputes — model your own program in the first meeting.

Executable classifier

A 9-sheet decision tool

Enter your program's profile and it returns the binding (rate-limiting) node, the matched strategy, the required assay panel, and a safety-critical contraindication — with its own decision rules, organ rules, archetype cards, validation log, and traceability map.

Provenance backbone

Every claim, traced to its source

Claim Ledger, Evidence Table, Source-Support Verdicts (supports exactly / partially / contradicts / insufficient), Source-Quality Summary, and a Traceability Certificate — each claim carrying a verbatim excerpt and identifier, retraction-checked.

Hypotheses & next studies

13+ falsifiable, pre-powered

A Hypotheses Ledger and a Most-Valuable-Next-Studies sheet: each hypothesis couples ≥2 mechanisms, predicts a readout, names its explicit disconfirming test, and pairs with a costed, powered next study.

Strategy trackers

The field, mapped

Asset & company tracker, trial-catalyst tracker, competitive landscape, regulatory-endpoint tracker, organ-strategy and cross-transfer matrices, and biomarker maps — the moving pieces of the field, sourced and current.

Nothing hidden

The work you usually never see

Excluded-claims and quarantined-source registers, a salvage ledger, a full verification & search log, a figure source map, a version registry, and an audit issues log — the discarded and contested material kept in the open.

The product

A Zemi Dossier compresses frontier uncertainty into an auditable action map.

These are not generic literature reviews, market summaries, or automated article bundles. They are premium medical research-intelligence products designed to help serious builders and funders decide where frontier medical research is actually investable, testable, strategically defensible, or too early.

01 / Decision report

Thesis, evidence, and buyer actions

Frames the domain, strategic thesis, opportunities, risks, limitations, near-discovery signals, and what different buyers should do next.

02 / Traceable workbook

Inspectable evidence infrastructure

Shows claim ledgers, evidence tables, source-support verdicts, excluded claims, score basis, traceability certificate, and audit surfaces.

03 / Falsifiable strategy

Hypotheses and gates

Converts conclusions into explicit, evidence-linked hypotheses, each with a primary endpoint and threshold, the named result that would falsify it, and the validation gates that would strengthen, weaken, or break the thesis. Near-discovery propositions, not proven claims.

04 / Next studies

Power-calculated execution bridge

Pairs each major hypothesis with population, intervention, comparator, and endpoint, then effect-size, alpha, target power, computed sample size, design sample size, budget, and timeline — and the buyer decision each study resolves.

Product proof

Preview the research report and workbook before opening the full dossier.

This preview shows how the Dossier format moves from evidence narrative to inspectable decision infrastructure: report preview, workbook power sheet, traceability surfaces, hypotheses, and limitations.

Research report preview First 30 pages of the report
Engineering Memory research report preview page 1 Engineering Memory research report preview page 2 Engineering Memory research report preview page 3 Engineering Memory research report preview page 4 Engineering Memory research report preview page 5 Engineering Memory research report preview page 6 Engineering Memory research report preview page 7 Engineering Memory research report preview page 8 Engineering Memory research report preview page 9 Engineering Memory research report preview page 10 Engineering Memory research report preview page 11 Engineering Memory research report preview page 12 Engineering Memory research report preview page 13 Engineering Memory research report preview page 14 Engineering Memory research report preview page 15 Engineering Memory research report preview page 16 Engineering Memory research report preview page 17 Engineering Memory research report preview page 18 Engineering Memory research report preview page 19 Engineering Memory research report preview page 20 Engineering Memory research report preview page 21 Engineering Memory research report preview page 22 Engineering Memory research report preview page 23 Engineering Memory research report preview page 24 Engineering Memory research report preview page 25 Engineering Memory research report preview page 26 Engineering Memory research report preview page 27 Engineering Memory research report preview page 28 Engineering Memory research report preview page 29 Engineering Memory research report preview page 30
Evidence & Decision Workbook Power sheet · computed values
Engineering Memory Power Calculations sheet showing computed sample sizes for each hypothesis
Live values from the workbook's Power Calculations sheet: editable assumptions (effect size, alpha, target power) drive each hypothesis to a computed sample size and a design n that carries dropout and enrichment. The licensed workbook keeps the underlying formulas, per-effect sensitivity bands, endpoints, budgets, and reconciliation notes alongside the evidence, claims, quarantine, traceability, classifier logic, and audit surfaces.
What a dossier lets you build

A dossier is a launchpad for discovery — not a dead end.

The slow, expensive, easy-to-get-wrong part of frontier research is the synthesis: reconciling hundreds of sources into a base of deep, non-obvious connections and falsifiable hypotheses no single reader could assemble. Once you own that base, you can carry a hypothesis past the literature into genuinely new findings. We prove it on our own dossiers — we took a hypothesis beyond the synthesis, pre-registered the analysis, ran it in open reproducible code, and published new frontier results. That advantage is what a dossier hands you.

Built on the fibrosis dossier

New single-cell evidence for the two-population law of fibrosis.

Starting from the dossier's synthesized base, we pushed its two-population hypothesis into new public-data analysis — four cohorts, 312,929 single cells — and found that matrix formation is molecularly decoupled from lung function and run by a different cell population than degradation. A genuinely new result that pinpoints the patients today's trials can't see. Published, pre-registered, reproducible.

Built on the reprogramming dossier

A new cross-organ finding about the substrate of epigenetic aging.

From the dossier's rejuvenation-transformation margin framework, we ran a new pre-registered cross-organ analysis and showed the PRC2 methylation "clock" is proliferation-linked (ρ = +0.85) — a novel result that sharpens the field's core rule (price the margin, not the clock) and opens a fresh question about where the reversible signal really lives. Frontier work the dossier's base made possible.

Both published open-access on Zenodo (CC BY 4.0), pre-registered on OSF, with reproducible code ORCID 0009-0003-6683-9335
How far a dossier can take you

A dossier tells you what to test. Its hypotheses can be carried all the way to a clinical trial design.

The synthesized base is what lets a team take one hypothesis — using only public data and simulation, no wet lab — to a trial-design-grade, pre-IND-ready design. To show what's possible, we did it on the fibrosis dossier and published the full trial design.

1
Ground the control arm

Replace assumptions with evidence — the number that decides everything.

2
Find the patients today's trials can't see

A biomarker-enrichment design from our own pre-registered analysis.

3
Discount the effect honestly

The true probability of success — a defensible number for an investment committee.

4
Simulate a design that de-risks itself

A 20,000-replication adaptive trial that stops early and cheaply when the effect isn't there.

5
Unlock the endpoint — the real product

The exact FDA qualification path that makes the trial legal in the first place.

Worked, published: Fibrosis

We carried the fibrosis dossier's Hypothesis 1 to a full clinical trial design — 22 linked analyses across ~19 disciplines. A single fixed trial was an honest 57% coin-flip, so we designed an adaptive trial that holds type-I at 2%, gives 82% power, and cuts enrollment from 160 to ~101 patients when the drug doesn't work.

See the fibrosis clinical trial design
Trial-design-grade, not IND-filed.

It does not run the trial, prove the biology, or replace toxicology. The efficacy effect is trial-measured. That honesty is the brand.

Dossier library

Browse the current catalog by domain.

This is the section the top Dossiers tab now lands on: the nine corrected domains, their primary Zemi Dossiers, and the package stats buyers need before choosing a dossier or domain page.

2 primary dossiers

Oncology

Cancer biology, molecular residual disease, recurrence prevention, immuno-oncology, therapeutic resistance, early intervention, and evidence standards for cancer programs.

3 primary dossiers

Immunology

Immune state, inflammatory memory, tolerance, autoimmunity, fibrosis, tissue resolution, neuro-immune control, and durable immune intervention endpoints.

3 primary dossiers

Gene Therapy

Therapeutic platforms that edit, replace, silence, repair, regulate, or compensate for DNA, RNA, chromatin, and variant-to-function disease mechanisms.

2 primary dossiers

Infectious Disease

Resistance, pathogen threat ranking, fungal disease, host vulnerability, diagnostics, antimicrobial precision, surveillance gaps, and countermeasure design.

2 primary dossiers

Rare Diseases

Small-population development, monogenic and mitochondrial disease, natural history, surrogate endpoints, variant interpretation, N-of-1 therapies, and evidence flexibility.

2 primary dossiers

Digital Health

Clinical AI, digital biomarkers, computational biology, prospective validation, deployment drift, sensor-derived measures, and decision utility.

4 primary dossiers

Neurology

Brain states, neural circuits, neurodegenerative biology, neural interfaces, closed-loop modulation, memory science, and neuro-immune control systems.

5 primary dossiers

Emerging Med Tech

New approach methodologies, organ-on-chip systems, biofabrication, perfusable tissues, xenotransplantation, platform devices, and translational engineering gates.

Why it holds up

What you can't get by reading the literature yourself.

A Zemi Dossier is the output of a process no individual reader can replicate: hundreds of sources synthesized, every claim independently audited, and every number traceable to where it came from — compressing months of analyst work into one decision-ready package.

See how it's built
01
Synthesis at impossible scale

Hundreds of papers, trials, registries, regulatory records, and company signals are read and reconciled — surfacing cross-field connections no single analyst spans.

02
Every claim independently audited

An AI auditor resolves each citation against live databases and tests whether the source actually supports the claim, so issues are corrected before release.

03
Complete traceability

Claims carry verbatim excerpts and page anchors; figures and power rows map back to identifiers. You can audit the dossier instead of trusting it.

04
Months of work, compressed

What would take a team months to assemble — less thoroughly — arrives decision-ready, with the excluded and quarantined work preserved.

Browse the dossier catalog

Nine medical domains, each with field-first decision dossiers — every package pairs a research report with an Evidence & Decision Workbook and power-calculated next studies.