Audit-trailed frontier medical decision dossiers

Medical evidence is outpacing diligence. Zemi turns it into decision-grade dossiers.

Fast-moving medical fields generate papers, trial updates, registry changes, platform claims, and company signals faster than teams can separate signal from noise. Zemi Research converts that evidence into a buyer-ready decision map: what is established, what is inferred, what remains hypothetical, what would prove or break the thesis, and what to build, fund, avoid, monitor, or test next.

The product is the dossier. Premium report + traceable workbook + falsifiable hypotheses + power-calculated next studies, built for research-use diligence and strategic planning. Not medical advice.
Evidence mapHundreds of claims and verified citations sorted into established, inferred, hypothetical, or quarantined
Decision logicBuyer actions for what to build, fund, avoid, monitor, or test next
Workbook trustClaims, sources, support verdicts, limitations, and audit surfaces
Study pathHypotheses translated into power-calculated next studies, budgets, and timelines
The product

A Zemi Dossier compresses frontier uncertainty into an auditable action map.

These are not generic literature reviews, market summaries, or automated article bundles. They are premium medical research-intelligence products designed to help serious builders and funders decide where frontier medical research is actually investable, testable, strategically defensible, or too early.

01 / Decision report

Thesis, evidence, and buyer actions

Frames the domain, strategic thesis, opportunities, risks, limitations, near-discovery signals, and what different buyers should do next.

02 / Traceable workbook

Inspectable evidence infrastructure

Shows claim ledgers, evidence tables, source-support verdicts, excluded claims, score basis, traceability certificate, and audit surfaces.

03 / Falsifiable strategy

Hypotheses and gates

Converts conclusions into explicit, evidence-linked hypotheses, each with a primary endpoint and threshold, the named result that would falsify it, and the validation gates that would strengthen, weaken, or break the thesis. Near-discovery propositions, not proven claims.

04 / Next studies

Power-calculated execution bridge

Pairs each major hypothesis with population, intervention, comparator, and endpoint, then effect-size, alpha, target power, computed sample size, design sample size, budget, and timeline — and the buyer decision each study resolves.

Product proof

Preview the research report and workbook before opening the full dossier.

This preview shows how the Dossier format moves from evidence narrative to inspectable decision infrastructure: report preview, workbook power sheet, traceability surfaces, hypotheses, and limitations.

Research report preview First 30 pages of the report
Engineering Memory research report preview page 1 Engineering Memory research report preview page 2 Engineering Memory research report preview page 3 Engineering Memory research report preview page 4 Engineering Memory research report preview page 5 Engineering Memory research report preview page 6 Engineering Memory research report preview page 7 Engineering Memory research report preview page 8 Engineering Memory research report preview page 9 Engineering Memory research report preview page 10 Engineering Memory research report preview page 11 Engineering Memory research report preview page 12 Engineering Memory research report preview page 13 Engineering Memory research report preview page 14 Engineering Memory research report preview page 15 Engineering Memory research report preview page 16 Engineering Memory research report preview page 17 Engineering Memory research report preview page 18 Engineering Memory research report preview page 19 Engineering Memory research report preview page 20 Engineering Memory research report preview page 21 Engineering Memory research report preview page 22 Engineering Memory research report preview page 23 Engineering Memory research report preview page 24 Engineering Memory research report preview page 25 Engineering Memory research report preview page 26 Engineering Memory research report preview page 27 Engineering Memory research report preview page 28 Engineering Memory research report preview page 29 Engineering Memory research report preview page 30
Evidence & Decision Workbook Power sheet · computed values
Engineering Memory Power Calculations sheet showing computed sample sizes for each hypothesis
Live values from the workbook's Power Calculations sheet: editable assumptions (effect size, alpha, target power) drive each hypothesis to a computed sample size and a design n that carries dropout and enrichment. The licensed workbook keeps the underlying formulas, per-effect sensitivity bands, endpoints, budgets, and reconciliation notes alongside the evidence, claims, quarantine, traceability, classifier logic, and audit surfaces.
Dossier library

Browse the current catalog by domain.

This is the section the top Dossiers tab now lands on: the nine corrected domains, their primary Zemi Dossiers, and the package stats buyers need before choosing a dossier or domain page.

2 primary dossiers

Oncology

Cancer biology, molecular residual disease, recurrence prevention, immuno-oncology, therapeutic resistance, early intervention, and evidence standards for cancer programs.

3 primary dossiers

Immunology

Immune state, inflammatory memory, tolerance, autoimmunity, fibrosis, tissue resolution, neuro-immune control, and durable immune intervention endpoints.

3 primary dossiers

Gene Therapy

Therapeutic platforms that edit, replace, silence, repair, regulate, or compensate for DNA, RNA, chromatin, and variant-to-function disease mechanisms.

2 primary dossiers

Infectious Disease

Resistance, pathogen threat ranking, fungal disease, host vulnerability, diagnostics, antimicrobial precision, surveillance gaps, and countermeasure design.

2 primary dossiers

Rare Diseases

Small-population development, monogenic and mitochondrial disease, natural history, surrogate endpoints, variant interpretation, N-of-1 therapies, and evidence flexibility.

2 primary dossiers

Digital Health

Clinical AI, digital biomarkers, computational biology, prospective validation, deployment drift, sensor-derived measures, and decision utility.

4 primary dossiers

Neurology

Brain states, neural circuits, neurodegenerative biology, neural interfaces, closed-loop modulation, memory science, and neuro-immune control systems.

5 primary dossiers

Emerging Med Tech

New approach methodologies, organ-on-chip systems, biofabrication, perfusable tissues, xenotransplantation, platform devices, and translational engineering gates.

Why it holds up

What you can't get by reading the literature yourself.

A Zemi Dossier is the output of a process no individual reader can replicate: hundreds of sources synthesized, every claim independently audited, and every number traceable to where it came from — compressing months of analyst work into one decision-ready package.

See how it's built
01
Synthesis at impossible scale

Hundreds of papers, trials, registries, regulatory records, and company signals are read and reconciled — surfacing cross-field connections no single analyst spans.

02
Every claim independently audited

An AI auditor resolves each citation against live databases and tests whether the source actually supports the claim, so issues are corrected before release.

03
Complete traceability

Claims carry verbatim excerpts and page anchors; figures and power rows map back to identifiers. You can audit the dossier instead of trusting it.

04
Months of work, compressed

What would take a team months to assemble — less thoroughly — arrives decision-ready, with the excluded and quarantined work preserved.

Browse the dossier catalog

Nine medical domains, each with field-first decision dossiers — every package pairs a research report with an Evidence & Decision Workbook and power-calculated next studies.