Decision spine
Frames the controlling thesis, evidence status, buyer implications, and research-use limits.
Neurology
Zemi Dossier
Research-use only
BCI / BSI Long-Term Stability
A decision package on separating recoverable decoder drift from irreversible signal-source loss in chronic neural interfaces and brain-spine systems.
Decision this dossier helps answer
Is performance decay a software problem, a biology/materials problem, or a mixed failure that requires a different validation plan?
Problem this dossier solves
Preserve the source before optimizing the decoder.
The dossier treats long-term interface performance as a failure-classification problem. If the neural code moved, adaptive decoding may recover value; if the source degraded, no decoder can restore what the implant can no longer measure.
What is moving: current field evidence and platform activity
What is unresolved: decision-grade proof, endpoint logic, and failure modes
What Zemi solves: evidence-gated next-study strategy
Full decision package
95-page research report plus 35-sheet Evidence & Decision Workbook
Buy now
$3,500$5,500Launch price
Controlling thesis
Preserve the source before optimizing the decoder.
The dossier treats long-term interface performance as a failure-classification problem. If the neural code moved, adaptive decoding may recover value; if the source degraded, no decoder can restore what the implant can no longer measure.
A Zemi Dossier turns uncertain emerging research into a decision package: what is known, what is inferred, what is hypothetical, what would falsify the thesis, and what should be built, funded, avoided, monitored, or validated next.
Research report preview
First 30 pages of the actual BCI / BSI Long-Term Stability research report.
The public page shows the real document style, density, evidence posture, and decision framing before a buyer requests access to the full Zemi Dossier package.
Research report
The research report is the argument. It is not the whole product.
The PDF research report is the structured argument: field status, evidence maturity, buyer implications, falsifiable hypotheses, power-calculated next studies, strategic recommendations, limitations, and traceability posture.
Inspectable infrastructure
Pairs the report with claim ledgers, evidence tables, power rows, audit surfaces, and decision tools.
Executable next studies
Links hypotheses to endpoint logic, assumptions, sample-size logic, budget, and timeline planning.
Research report table of contents
Public TOC generated from the source report.
The full research report is delivered as a licensed PDF. This table shows the decision structure without publishing the full product.
| Section | What it covers | Buyer value |
|---|---|---|
| Decision Brief | Turns the report into immediate buyer triage: what matters now, what is still uncertain, and what to do next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Decision brief - read this first | Turns the report into immediate buyer triage: what matters now, what is still uncertain, and what to do next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Executive Summary | Condenses the dossier thesis, evidence posture, buyer implications, and next-study priorities. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Scope and Evidence Integrity | Defines the evidence window, source boundaries, research-use limits, and labeling discipline. | Lets the buyer audit support strength before relying on the package. |
| Scope and evidence-integrity statement | Defines the evidence window, source boundaries, research-use limits, and labeling discipline. | Lets the buyer audit support strength before relying on the package. |
| How directness was graded, and why zero-direct is the spine | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The labeling discipline, applied consistently | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Denominator Definitions | Defines the populations, measurements, or comparison bases needed to interpret evidence without overgeneralizing. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Denominator-definitions box | Defines the populations, measurements, or comparison bases needed to interpret evidence without overgeneralizing. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Decision Snapshot Overview | Maps findings to buyer actions: build, fund, avoid, monitor, or validate next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Decision snapshot | Maps findings to buyer actions: build, fund, avoid, monitor, or validate next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The reasoning behind each verdict | Links claims to source support so users can separate what is known, inferred, and hypothetical. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Buyer Decision Cheat Sheet | Maps findings to buyer actions: build, fund, avoid, monitor, or validate next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Buyer decision cheat sheet | Maps findings to buyer actions: build, fund, avoid, monitor, or validate next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Source Quality Dashboard | Shows how strong the source base is and where conclusions depend on indirect or thinner support. | Lets the buyer audit support strength before relying on the package. |
| Source-quality dashboard | Shows how strong the source base is and where conclusions depend on indirect or thinner support. | Lets the buyer audit support strength before relying on the package. |
| Fidelity Decay Model | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The Fidelity-Decay Stack: the controlling model | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Six layers, one product | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The law that makes the stack generative | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The SIROF refinement: preserve the functional source, not the structure | Links claims to source support so users can separate what is known, inferred, and hypothetical. | Lets the buyer audit support strength before relying on the package. |
| The refinement that makes the law operational: diagnose before you decode | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The model validated from the outside | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Why the layers multiply rather than add — and what that buys analytically | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The six layers, read as a coupled dynamical system | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Current Signal Update 2025 2026 | Frames the field's June 2026 state, active programs, research fronts, and timing signals. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| 2025-2026 current-signal update — the forward-looking core | Frames the field's June 2026 state, active programs, research fronts, and timing signals. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Industry and regulatory (company- or regulator-reported; designation is not approval) | Connects research maturity to competitive position, program strategy, and diligence watchpoints. | Connects research claims to practical diligence and monitoring decisions. |
| Science (2025-2026, newly surfaced and verified) | Frames the field's June 2026 state, active programs, research fronts, and timing signals. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Net read | Summarizes the most decision-relevant findings and their implications for the dossier thesis. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The mid-2026 frontier cut (premium fresh scan) | Frames the field's June 2026 state, active programs, research fronts, and timing signals. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Cross Layer Convergence Map | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Cross-layer convergence: the couplings that decide the window | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Two couplings the 2026 evidence adds | Frames the field's June 2026 state, active programs, research fronts, and timing signals. | Lets the buyer audit support strength before relying on the package. |
| Which couplings are actionable now, and how they feed the classifier | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Gives the buyer a reusable way to compare programs, risks, and evidence states. |
| Cross Domain Synthesis | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
Evidence & Decision Workbook
The workbook is the decision engine.
A locked public preview of selected workbook-derived sheets: sheet structure, decision modules, power rows, traceability, and audit posture. Licensed buyers receive the full workbook files.
Read-only workbook preview with clipped values and no formulas. Licensed buyers receive the full Evidence & Decision Workbook with editable assumptions and working files.
Workbook inventory
Delivered workbook sheets.
Full inventories belong on dossier pages, not the homepage. Sheet names below are extracted from the actual workbook file.
| # | Workbook sheet | What it does |
|---|---|---|
| 1 | Workbook Guide | Navigation layer for using the workbook, understanding sheet roles, and following the decision package. Public preview exposes Dossier, Preserve the Source, Decode the. fields and clipped entries such as Source run, evidence pack task:346e955212a67dd0.,. |
| 2 | Claim Ledger | Claim-by-claim ledger showing verdicts, source support, inference status, and decision relevance. Public preview exposes claim_id, claim_text, report_section, decay_layer* fields and clipped entries such as K001, Flexible polyimide neural probes., Key. |
| 3 | Evidence Table | Evidence-verification surface for checking sources, support quality, and the audit trail. Public preview exposes claim_label, primary_citation, study_design, sample_size fields and clipped entries such as Finding 1 — Flexible polyimide., PMID:41727007, Not. |
| 4 | Source-Support Verdicts | Independent check on whether key claims are actually supported by cited sources. Public preview exposes claim_id, primary_identifier, resolved, retracted fields and clipped entries such as K001, PMID:41727007, No (screened). |
| 5 | Source Quality Summary | Summary of source strength, gaps, and areas where conclusions depend on weaker evidence. Public preview exposes Total customer-facing claims, 84 fields and clipped entries such as Excluded claims, 80 (73 off-topic, 3 structural, 4., Recovered from excluded. |
| 6 | Intervention Scorecard | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Intervention, Signal-Source, Tissue-Interface, Material/Mech fields and clipped entries such as Soft/compliant substrates, Irrecoverable,. |
| 7 | Layer Scorecard | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Decay layer, Evidence maturity (0-3), Intervention readiness (0-3), Dominant failure type fields and clipped entries such as Signal-Source. |
| 8 | Device-Material Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes Material / coating / electrode, Type, Key property (verified), In-vivo status / max follow-up fields and clipped entries such as SIROF (sputtered. |
| 9 | Asset-Sponsor Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes Sponsor / platform, Modality, Channels (reported), Stage (2026) fields and clipped entries such as Neuralink (N1/PRIME), Penetrating flexible. |
| 10 | Trial-Catalyst Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes Identifier / study, Title, Status, Phase fields and clipped entries such as NCT07457645, High-Channel Implanted BCI for Motor., NOT_YET_RECRUITING. |
| 11 | Failure-Mode Tracker | Captures failure modes and constraints that could invalidate or narrow a program. Public preview exposes Failure mode, Timing, Reversibility, Severity (expert) fields and clipped entries such as Insertion trauma / BBB breach, Acute, Irrecoverable. |
| 12 | Biomarker-Endpoint Map | Tracks biomarkers or readouts that determine whether the thesis is moving toward testable evidence. Public preview exposes Biomarker, Interface metric / endpoint, Failure mode reflected, Action routed fields and clipped entries such as 1 kHz impedance. |
| 13 | Regulatory Tracker | Tracks regulatory, endpoint, reimbursement, or qualification requirements that shape testing strategy. Public preview exposes Sponsor, Channel, Status, Date fields and clipped entries such as Precision Neuroscience, 510(k) clearance (K242618), Cleared (<=30. |
| 14 | Figure Source Map | Traceability surface linking claims, figures, calculations, and workbook outputs back to sources. Public preview exposes figure_id, figure_title, figure_family, section_anchor fields and clipped entries such as fig01_grade_recalibration, Evidence-grade. |
| 15 | Figure Attempt Ledger | Figure and numeric reproduction log for validating calculations, chart inputs, or displayed values. Public preview exposes figure_id, backend, data_type, buyer_question_answered fields and clipped entries such as fig01_grade_recalibration, deterministic,. |
| 16 | Hypotheses Ledger | Maps hypotheses to evidence state, falsification logic, endpoints, and next-study design. Public preview exposes id, tier, paradigm, axis (layers) fields and clipped entries such as F1, Flagship, Computation x Material x Tissue x.. |
| 17 | Most Valuable Next Studies | Prioritizes next studies that could change the decision, including endpoints and evidence gates. Public preview exposes #, Study, Question, Design fields and clipped entries such as Chronic-human molecular taxonomy, Does the rodent mechanism set hold.,. |
| 18 | Verification-Search Log | Release-discipline surface for revisions, unresolved issues, audit findings, and readiness tracking. Public preview exposes full-text support adjudication, Every customer-facing claim., 84 fields and clipped entries such as pubmed, intracortical. |
| 19 | Excluded Claims | Disposition log for rejected, bounded, or quarantined claims so they do not leak into the decision thesis. Public preview exposes claim_id, set, label, primary fields and clipped entries such as O001, offtopic, Excluded 4 — Dysregulated eEF2K/eEF2.. |
| 20 | Salvage Ledger | Disposition log for rejected, bounded, or quarantined claims so they do not leak into the decision thesis. Public preview exposes Source element, Action, Rationale fields and clipped entries such as Three-domain framing., REUSE+IMPROVE, Sharpened into the. |
| 21 | FDC_Input_Template | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Peri-electrode inflammation., active source degradation, 0-3 (3 = high) fields and clipped entries such as Recordable single-unit count trend,. |
| 22 | FDC_Feature_Score | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Failure class (output), Rubric (3 = strong evidence for., Evidence 0-3 (ENTER), Weight (expert-init) fields and clipped entries such as. |
| 23 | FDC_Class_Output | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Archetype (evidence scores), Dominant class, Confidence, OUTPUT / guard fields and clipped entries such as Recoverable-drift (ECoG, units.,. |
| 24 | FDC_Decision_Rules | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Failure class, Recommended action, Primary functional endpoint, Required safety readout fields and clipped entries such as RECOVERABLE-DRIFT,. |
| 25 | FDC_Modality_Rules | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes penetrating, HIGH source-loss prior., IRRECOVERABLE-TERMINAL-LOSS /., impedance trajectory +. fields and clipped entries such as Penetrating, HIGH. |
| 26 | FDC_Minimum_Assay_Panel | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Recordable single-unit count /., source attrition, Required fields and clipped entries such as Neural-manifold geometry (on-device),. |
| 27 | FDC_Archetype_Cards | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Slow-source-degradation, inflammation/impedance 3;., SLOW-SOURCE-DEGRADATION, Neuroprotect the population fields and clipped entries such as. |
| 28 | FDC_Validation_Log | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Functional endpoint, functional channel-years. fields and clipped entries such as Calibration, required (reliability of., Weights. |
| 29 | FDC_Traceability_Map | Traceability surface linking claims, figures, calculations, and workbook outputs back to sources. Public preview exposes FDC element, Maps to finding, Evidence ID, Figure fields and clipped entries such as Impedance-slope input, kf-functional-longevity;. |
| 30 | Power Calculations | Power-calculation layer for assumptions, endpoint logic, computed sample sizes, and sensitivity checks. Public preview exposes hypothesis_id, study_id, endpoint, test_type fields and clipped entries such as F1, STU-F1, Classifier AUC for four-week-ahead.. |
| 31 | Score Basis | Explains how scores or ratings were assigned so the decision instrument can be inspected. Public preview exposes fig01 buyer dashboard (GO..NO-GO), GO=4..NO-GO=1, investability by. fields and clipped entries such as fig07 layer scorecard, 0-3, per-layer. |
| 32 | Traceability Certificate | Traceability surface linking claims, figures, calculations, and workbook outputs back to sources. Public preview exposes claim_id, report_section, report_page, claim_text fields and clipped entries such as K001, Key Findings & Data Analysis, § Key Findings &. |
| 33 | Competitive Landscape | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes Company, Asset / platform, Modality, Target / indication fields and clipped entries such as Neuralink, N1 / PRIME, Penetrating flexible threads,. |
| 34 | Version Registry | Release-discipline surface for revisions, unresolved issues, audit findings, and readiness tracking. Public preview exposes Dossier v2.0 (premium), June 2026, Premium Tier C elevation from the., Reviewer (Opus 4.8) fields and clipped entries such as. |
| 35 | Audit Issues Log | Release-discipline surface for revisions, unresolved issues, audit findings, and readiness tracking. Public preview exposes #, Issue, Status, Resolution fields and clipped entries such as AI-1, Workbook genuinely executable?, RESOLVED. |
Power-calculated next studies
Power calculations are the execution bridge.
Power calculations are planning-grade research calculations for endpoint logic, assumptions, sample size, budget, and timeline. They do not prove hypotheses or constitute clinical protocol.
| Hypothesis | Primary endpoint | Test | Effect | α | Power | Computed n | Design n |
|---|---|---|---|---|---|---|---|
| F1 | Classifier AUC for four-week-ahead recoverable-vs-irrecoverable | AUC (Hanley-McNeil, external) | 0.85 | 0.05 | 0.80 | 48 | 60 |
| F2 | Shape of decode-accuracy vs recordable-unit-count trajectory (pr | two-sample means (Cohen d) | 0.8 | 0.05 | 0.80 | 25 | 30 |
| F3 | Predictive value of electrochemical vs mechanical metrics for 24 | two-proportion, pooled | 0.6 | 0.05 | 0.80 | 62 | 64 |
| R1 | Chronic yield vs Piezo1-inhibition dose (test for U-shape); pass | two-sample means (Cohen d) | 0.8 | 0.05 | 0.80 | 25 | 8 |
| R2 | Chronic yield and GFAP by arm (TREK-1 vs Piezo1 vs combination v | two-sample means (Cohen d) | 0.8 | 0.05 | 0.80 | 25 | 8 |
Release audit discipline
Audit posture is part of the product.
Public pages do not publish exact audit scores. They should state the release discipline, revision posture, and limitations without implying peer review or validated clinical guidance.
Research-use decision package
Not medical advice, clinical guidance, investment advice, or a clinical protocol.
Known / inferred / hypothetical
The package separates cited evidence from inference and frontier hypothesis generation.
Audit-gated and revision-controlled
Adversarial audit checks source support, formulas, figures, limitations, and release readiness.
Buy this dossier
Full decision package — 95-page report + 35-sheet workbook
Buy now
- Decision research report (95 pages, PDF)
- Evidence & Decision Workbook (35 sheets, .xlsx) — claims, source-support verdicts, power calculations, traceability, and audit log
- Live, editable power-calculated next studies
$3,500$5,500Launch price