Decision spine
Frames the controlling thesis, evidence status, buyer implications, and research-use limits.
Neurology
Zemi Dossier
Research-use only
Engineering Memory / Engrams
A decision package on whether memory programs should re-access, edit, stabilize, reconstruct, or avoid intervention based on the state of the memory trace.
Decision this dossier helps answer
Which memory programs are actually testable, and what state classifier must exist before choosing an intervention?
Problem this dossier solves
Memory intervention is a routing problem before it is a modality problem.
The dossier argues that memory programs fail when they treat storage loss, retrieval lock, lability, durability, and specificity as one problem. The decision package turns those hidden states into research-use routing logic.
What is moving: current field evidence and platform activity
What is unresolved: decision-grade proof, endpoint logic, and failure modes
What Zemi solves: evidence-gated next-study strategy
Full decision package
118-page research report plus 38-sheet Evidence & Decision Workbook
Buy now
$3,500$5,500Launch price
Controlling thesis
Memory intervention is a routing problem before it is a modality problem.
The dossier argues that memory programs fail when they treat storage loss, retrieval lock, lability, durability, and specificity as one problem. The decision package turns those hidden states into research-use routing logic.
A Zemi Dossier turns uncertain emerging research into a decision package: what is known, what is inferred, what is hypothetical, what would falsify the thesis, and what should be built, funded, avoided, monitored, or validated next.
Research report preview
First 30 pages of the actual Engineering Memory / Engrams research report.
The public page shows the real document style, density, evidence posture, and decision framing before a buyer requests access to the full Zemi Dossier package.
Research report
The research report is the argument. It is not the whole product.
The PDF research report is the structured argument: field status, evidence maturity, buyer implications, falsifiable hypotheses, power-calculated next studies, strategic recommendations, limitations, and traceability posture.
Inspectable infrastructure
Pairs the report with claim ledgers, evidence tables, power rows, audit surfaces, and decision tools.
Executable next studies
Links hypotheses to endpoint logic, assumptions, sample-size logic, budget, and timeline planning.
Research report table of contents
Public TOC generated from the source report.
The full research report is delivered as a licensed PDF. This table shows the decision structure without publishing the full product.
| Section | What it covers | Buyer value |
|---|---|---|
| Decision Brief | Turns the report into immediate buyer triage: what matters now, what is still uncertain, and what to do next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Correction Status | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Executive Summary | Condenses the dossier thesis, evidence posture, buyer implications, and next-study priorities. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Scope and Evidence Integrity | Defines the evidence window, source boundaries, research-use limits, and labeling discipline. | Lets the buyer audit support strength before relying on the package. |
| Decision Snapshot Overview | Maps findings to buyer actions: build, fund, avoid, monitor, or validate next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Buyer Matrix | Operationalizes the thesis as a reusable decision surface for comparing programs or evidence states. | Gives the buyer a reusable way to compare programs, risks, and evidence states. |
| Buyer Decision Dashboard | Maps findings to buyer actions: build, fund, avoid, monitor, or validate next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Source Quality Dashboard | Shows how strong the source base is and where conclusions depend on indirect or thinner support. | Lets the buyer audit support strength before relying on the package. |
| Engram State Model | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The model: classify the state, match the modality, act in the window, engineer the specificity, govern the self | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Law 1 - Lost-not-Locked is the floor, not the discovery (the diagnostic keystone) | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Law 2 - Durability equals malleability, but the dial may be separable | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Law 3 - Reconsolidation is a dose-response in prediction-error space (the Mismatch-Dose law) | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Law 4 - Specificity is set by the glial-inhibitory envelope, not the neuron (the Specificity law) | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The meta-gate - the species and inferential ladder prices every claim | Links claims to source support so users can separate what is known, inferred, and hypothetical. | Gives the buyer a reusable way to compare programs, risks, and evidence states. |
| What the model implies - the flagship architecture | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Scoring a program with the Stack - a worked example | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Current Signal Update | Frames the field's June 2026 state, active programs, research fronts, and timing signals. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Current Signal Refresh | Frames the field's June 2026 state, active programs, research fronts, and timing signals. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Cross Domain Convergence Map | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Coupling 1 - The Lost/Locked synaptic signature x the human diagnostic gap | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Coupling 2 - Mismatch dose x the cross-indication reconsolidation lever (PTSD, SUD, chronic pain are one disease here) | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Coupling 3 - The glial-inhibitory specificity envelope x the optogenetic specificity ceiling | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Coupling 4 - Chromatin-loop persistence x reconsolidation-window variation by memory age | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Coupling 5 - The endogenous attractor x the species-incompatible memory code (the prosthetic reframe) | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Coupling 6 - Sleep-replay timing x modality (the cheapest specificity-and-durability multiplier) | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Coupling 7 - The durability=malleability dial x the compromised brain (why editing is most dangerous where it is most needed) | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Coupling 8 - Memory enhancement and memory repair are one machine pointed in opposite directions | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Evidence Maturity and Modality Matrix | Links claims to source support so users can separate what is known, inferred, and hypothetical. | Gives the buyer a reusable way to compare programs, risks, and evidence states. |
| Evidence-Maturity Matrix (by strategy) | Links claims to source support so users can separate what is known, inferred, and hypothetical. | Gives the buyer a reusable way to compare programs, risks, and evidence states. |
| Comparative-Modality Matrix (engineering axes) | Operationalizes the thesis as a reusable decision surface for comparing programs or evidence states. | Gives the buyer a reusable way to compare programs, risks, and evidence states. |
| Key Findings | Summarizes the most decision-relevant findings and their implications for the dossier thesis. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Locked state (molecular lock) | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Locked state (dementia re-access) | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Lost vs Locked (synaptic signature) | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Lost state (storage degradation) | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
Evidence & Decision Workbook
The workbook is the decision engine.
A locked public preview of selected workbook-derived sheets: sheet structure, decision modules, power rows, traceability, and audit posture. Licensed buyers receive the full workbook files.
Read-only workbook preview with clipped values and no formulas. Licensed buyers receive the full Evidence & Decision Workbook with editable assumptions and working files.
Workbook inventory
Delivered workbook sheets.
Full inventories belong on dossier pages, not the homepage. Sheet names below are extracted from the actual workbook file.
| # | Workbook sheet | What it does |
|---|---|---|
| 1 | Workbook Guide | Navigation layer for using the workbook, understanding sheet roles, and following the decision package. Public preview exposes Internal screen (superseded), The source pack's strict. fields and clipped entries such as Species/inference discipline, Every. |
| 2 | Claim Ledger | Claim-by-claim ledger showing verdicts, source support, inference status, and decision relevance. Public preview exposes claim_id, claim_text, report_section, report_page fields and clipped entries such as K001, Memory neurofeedback using., Key Findings &. |
| 3 | Evidence Table | Evidence-verification surface for checking sources, support quality, and the audit trail. Public preview exposes identifier, title, journal, year fields and clipped entries such as PMID:22441246, Optogenetic stimulation of a., Nature. |
| 4 | Source-Support Verdicts | Independent check on whether key claims are actually supported by cited sources. Public preview exposes claim_id, primary, verdict, support_signal fields and clipped entries such as K001, PMID:41453292, SUPPORTS_EXACTLY. |
| 5 | Source Quality Summary | Summary of source strength, gaps, and areas where conclusions depend on weaker evidence. Public preview exposes Kept claim records, 87 fields and clipped entries such as Customer-facing claims (YES +., Appendix-only claim records.. |
| 6 | Modality-EngramState Scorecard | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes modality, addresses_state, specificity (0-4), window_engaged (0-4) fields and clipped entries such as Pharmacological., edit / re-access,. |
| 7 | Lability-Window Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes lifecycle_stage, what is writable, key modality, representative source(s) fields and clipped entries such as Encoding / allocation, which neurons. |
| 8 | Indication Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes indication, findings, human-interventional, example sources fields and clipped entries such as PTSD fear trauma, PMID:22441246; PMID:39549697;.,. |
| 9 | Lost-vs-Locked Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes finding, state, signature / mechanism, indication fields and clipped entries such as GluA2-AMPAR endocytosis silences., LOCKED, synaptic AMPAR. |
| 10 | Reconsolidation-Specificity | Workbook surface supporting a specific evidence, decision, study-planning, or release-control workflow. Public preview exposes lever / mechanism, function, specificity layer, indication fields and clipped entries such as Noradrenaline -> CRTC1,. |
| 11 | Engram-Epigenetics | Workbook surface supporting a specific evidence, decision, study-planning, or release-control workflow. Public preview exposes finding, mechanism, relevance, species fields and clipped entries such as Persistent chromatin loops in engram., activity-dependent. |
| 12 | Asset & Company Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes asset / program, sponsor / lab, modality, stage / status fields and clipped entries such as Nia Therapeutics AI-guided memory., Nia Therapeutics. |
| 13 | Trial-Catalyst Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes identifier, title / program, indication, modality fields and clipped entries such as NCT05902819, Minocycline reconsolidation., PTSD + cocaine use. |
| 14 | Near-Discovery Watch List | Monitoring surface for emerging signals, update triggers, and evidence changes that could alter the decision. Public preview exposes near-discovery readout (2026-2028), paradigm?, makes (confirms), breaks (refutes) fields and clipped entries such as Human. |
| 15 | Regulatory & Endpoint Tracker | Tracks regulatory, endpoint, reimbursement, or qualification requirements that shape testing strategy. Public preview exposes modality, regulatory channel (named), status, key evidence-standard / endpoint fields and clipped entries such as Memory prosthesis. |
| 16 | Biomarker-Endpoint Map | Tracks biomarkers or readouts that determine whether the thesis is moving toward testable evidence. Public preview exposes candidate biomarker, reads, clinical decision enabled, maturity fields and clipped entries such as AMPA-receptor / GluA2 imaging,. |
| 17 | Figure Source Map | Traceability surface linking claims, figures, calculations, and workbook outputs back to sources. Public preview exposes figure_id, figure_title, figure_family, section_anchor fields and clipped entries such as fig01_grade_recalibration, Evidence,. |
| 18 | Figure Attempt Ledger | Figure and numeric reproduction log for validating calculations, chart inputs, or displayed values. Public preview exposes figure_id, figure_family, data_type, evidence_grade fields and clipped entries such as fig01_grade_recalibration,. |
| 19 | Hypotheses Ledger | Maps hypotheses to evidence state, falsification logic, endpoints, and next-study design. Public preview exposes H#, Tier, class, paradigm? fields and clipped entries such as H1, Flagship, Mechanistic. |
| 20 | Most Valuable Next Studies | Prioritizes next studies that could change the decision, including endpoints and evidence gates. Public preview exposes study, population, intervention, comparator fields and clipped entries such as Lost-vs-Locked stratified re-access., signature-phenotyped. |
| 21 | Verification & Search Log | Release-discipline surface for revisions, unresolved issues, audit findings, and readiness tracking. Public preview exposes ClinicalTrials.gov v2, 15 NCTs (incl. 6 final., status/phase/results/sponsor, 15/15 resolved fields and clipped entries such as. |
| 22 | Excluded Claims & Quarantine | Disposition log for rejected, bounded, or quarantined claims so they do not leak into the decision thesis. Public preview exposes claim_id, disposition, claim (short), primary fields and clipped entries such as B001, beyond_capacity, A review on. |
| 23 | Salvage Ledger | Disposition log for rejected, bounded, or quarantined claims so they do not leak into the decision thesis. Public preview exposes recovered / added source, origin, why valuable, fold-in fields and clipped entries such as Multimodal cognitive-state decoding.,. |
| 24 | Power Calculations | Power-calculation layer for assumptions, endpoint logic, computed sample sizes, and sensitivity checks. Public preview exposes hypothesis_id, study_id, endpoint, test_type fields and clipped entries such as H1, ENG-RECON-DOSE, Target-memory update magnitude. |
| 25 | ESC_Input_Template | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Durability, forgetting rate /., Feature_Score C7 (DURABILITY), 0 fields and clipped entries such as Specificity / collateral, engram overlap,. |
| 26 | ESC_Feature_Score | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Axis (output class), Maps to Input-Template axis., Deficit 0-3 (=Input_Template!D), Weight (expert-init) fields and clipped entries such as. |
| 27 | ESC_Class_Output | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Evidence completeness. fields from this sheet. |
| 28 | ESC_Decision_Rules | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Class (binding constraint), Recommended strategy, Primary functional endpoint, Required safety readout fields and clipped entries such as. |
| 29 | ESC_State_Rules | Workbook surface supporting a specific evidence, decision, study-planning, or release-control workflow. Public preview exposes Engram-state determination (keyed., State-matched strategy, Contraindication, Safety flag fields and clipped entries such as LOST,. |
| 30 | ESC_Minimum_Assay_Panel | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Lability/replay-window status., Window, Required fields and clipped entries such as Mismatch / prediction-error., Window / edit, Preferred. |
| 31 | ESC_Archetype_Cards | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Archetype, Profile (deficits), Binding constraint, State fields and clipped entries such as Locked-retrieval-limited (flagship), retrieval 3, rest. |
| 32 | ESC_Validation_Log | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Status, RESEARCH-USE-ONLY,. fields and clipped entries such as Linked flagship, H5 (the keystone): a Lost-vs-Locked., Validation cohort (planned). |
| 33 | ESC_Traceability_Map | Traceability surface linking claims, figures, calculations, and workbook outputs back to sources. Public preview exposes ESC element, Maps to finding / claim, Evidence ID, Figure fields and clipped entries such as Storage vs retrieval axis (Lost vs.,. |
| 34 | Traceability Certificate | Traceability surface linking claims, figures, calculations, and workbook outputs back to sources. Public preview exposes #, claim_id, claim_text (exact), report_section fields and clipped entries such as K001, Memory neurofeedback using., Key Findings & Data. |
| 35 | Score Basis | Explains how scores or ratings were assigned so the decision instrument can be inspected. Public preview exposes fig01_grade_recalibration, evidence_grade_distribution, 0-4 expert ordinal., What is the evidence actually. fields and clipped entries such as. |
| 36 | Competitive Landscape | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes Entity, Asset / platform, Modality, Engram-state axis fields and clipped entries such as Graff lab / EPFL (Neuroepigenetics), OSK. |
| 37 | Version Registry | Release-discipline surface for revisions, unresolved issues, audit findings, and readiness tracking. Public preview exposes Engram-State Classifier (ESC), v1.0 (expert-initialized;., specified for prospective., - fields and clipped entries such as Flagship. |
| 38 | Audit Issues Log | Release-discipline surface for revisions, unresolved issues, audit findings, and readiness tracking. Public preview exposes #, Issue, Status, Resolution fields and clipped entries such as AI-1, No live Power Calculations sheet., RESOLVED. |
Power-calculated next studies
Power calculations are the execution bridge.
Power calculations are planning-grade research calculations for endpoint logic, assumptions, sample size, budget, and timeline. They do not prove hypotheses or constitute clinical protocol.
| Hypothesis | Primary endpoint | Test | Effect | α | Power | Computed n | Design n |
|---|---|---|---|---|---|---|---|
| H1 | Target-memory update magnitude vs mismatch dose (non-monotonic, withi... | Paired (within) | 0.5 | 0.05 | 0.80 | 32 | 48 |
| H2 | Dissociation index = content-update / retention-loss (agent vs vehicle) | Two-sample means | 1.0 | 0.05 | 0.80 | 16 | 20 |
| H3 | Off-target (adjacent-memory) change at equal target effect, across 3 ... | Two-sample means | 0.9 | 0.05 | 0.80 | 20 | 24 |
| H4 | Destabilization threshold vs memory-age x epigenetic-editor (interact... | Two-sample means | 1.25 | 0.05 | 0.80 | 11 | 12 |
| H5 | Autobiographical-access gain: Locked vs Lost arms vs sham; signature ... | Two-sample means | 0.682 | 0.05 | 0.80 | 34 | 150 |
Release audit discipline
Audit posture is part of the product.
Public pages do not publish exact audit scores. They should state the release discipline, revision posture, and limitations without implying peer review or validated clinical guidance.
Research-use decision package
Not medical advice, clinical guidance, investment advice, or a clinical protocol.
Known / inferred / hypothetical
The package separates cited evidence from inference and frontier hypothesis generation.
Audit-gated and revision-controlled
Adversarial audit checks source support, formulas, figures, limitations, and release readiness.
Buy this dossier
Full decision package — 118-page report + 38-sheet workbook
Buy now
- Decision research report (118 pages, PDF)
- Evidence & Decision Workbook (38 sheets, .xlsx) — claims, source-support verdicts, power calculations, traceability, and audit log
- Live, editable power-calculated next studies
$3,500$5,500Launch price