Decision spine
Frames the controlling thesis, evidence status, buyer implications, and research-use limits.
Gene Therapy
Zemi Dossier
Research-use only
RNA Editing & the Permanence Spectrum
A decision package on when reversible RNA editing is an advantage, when it is a liability, and what half-life logic controls the strategy.
Decision this dossier helps answer
Which RNA-editing programs should rent correction, extend correction, or avoid RNA-level strategy based on permanence needs?
Problem this dossier solves
RNA editing rents the correction; the question is whether renting is enough.
The dossier evaluates RNA editing by matching correction half-life to disease need, delivery burden, safety, and monitoring. It helps buyers decide when reversibility is the product and when it exposes a durability gap.
What is moving: current field evidence and platform activity
What is unresolved: decision-grade proof, endpoint logic, and failure modes
What Zemi solves: evidence-gated next-study strategy
Full decision package
112-page research report plus 39-sheet Evidence & Decision Workbook
Buy now
$3,500$5,500Launch price
Controlling thesis
RNA editing rents the correction; the question is whether renting is enough.
The dossier evaluates RNA editing by matching correction half-life to disease need, delivery burden, safety, and monitoring. It helps buyers decide when reversibility is the product and when it exposes a durability gap.
A Zemi Dossier turns uncertain emerging research into a decision package: what is known, what is inferred, what is hypothetical, what would falsify the thesis, and what should be built, funded, avoided, monitored, or validated next.
Research report preview
First 30 pages of the actual RNA Editing & the Permanence Spectrum research report.
The public page shows the real document style, density, evidence posture, and decision framing before a buyer requests access to the full Zemi Dossier package.
Research report
The research report is the argument. It is not the whole product.
The PDF research report is the structured argument: field status, evidence maturity, buyer implications, falsifiable hypotheses, power-calculated next studies, strategic recommendations, limitations, and traceability posture.
Inspectable infrastructure
Pairs the report with claim ledgers, evidence tables, power rows, audit surfaces, and decision tools.
Executable next studies
Links hypotheses to endpoint logic, assumptions, sample-size logic, budget, and timeline planning.
Research report table of contents
Public TOC generated from the source report.
The full research report is delivered as a licensed PDF. This table shows the decision structure without publishing the full product.
| Section | What it covers | Buyer value |
|---|---|---|
| Decision Brief Read This First | Turns the report into immediate buyer triage: what matters now, what is still uncertain, and what to do next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Contents | Shows the report structure and where to inspect the argument, evidence, workbook logic, and limits. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Executive Summary | Condenses the dossier thesis, evidence posture, buyer implications, and next-study priorities. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Scope and Evidence Integrity | Defines the evidence window, source boundaries, research-use limits, and labeling discipline. | Lets the buyer audit support strength before relying on the package. |
| Decision Snapshot Overview | Maps findings to buyer actions: build, fund, avoid, monitor, or validate next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Buy Build Wait Avoid | Maps findings to buyer actions: build, fund, avoid, monitor, or validate next. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Buyer Decision Matrix | Maps findings to buyer actions: build, fund, avoid, monitor, or validate next. | Gives the buyer a reusable way to compare programs, risks, and evidence states. |
| Source Quality Dashboard | Shows how strong the source base is and where conclusions depend on indirect or thinner support. | Lets the buyer audit support strength before relying on the package. |
| The Permanence Match Ledger | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Permanence Match Indication Fit Classifier Pmc | Operationalizes the thesis as a reusable decision surface for comparing programs or evidence states. | Gives the buyer a reusable way to compare programs, risks, and evidence states. |
| Indication By Indication Pmc Walkthrough | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Current Signal Refresh 2025 2026 | Frames the field's June 2026 state, active programs, research fronts, and timing signals. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Cross Axis Convergence Map | Shows how separate research signals converge, diverge, or interact across domains, mechanisms, or study layers. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Evidence Maturity and Modality Matrix | Links claims to source support so users can separate what is known, inferred, and hypothetical. | Gives the buyer a reusable way to compare programs, risks, and evidence states. |
| Comparative Modality Mechanism Matrix | Operationalizes the thesis as a reusable decision surface for comparing programs or evidence states. | Gives the buyer a reusable way to compare programs, risks, and evidence states. |
| Key Findings | Summarizes the most decision-relevant findings and their implications for the dossier thesis. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| The AATD natural experiment | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Rent-the-correction | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Half-life bifurcation | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Delivery-decides-fate | Identifies translational, regulatory, safety, or delivery constraints that shape whether the thesis can be tested. | Shows where the thesis could fail or require more validation before action. |
| Chassis-sets-permanence | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Permanence spectrum | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| ADAR-availability ceiling | Defines the governing argument and the evidence gates that would support or falsify it. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Self-resolving specificity tax | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Editing mechanism | Explains which biological signals matter for interpreting the field and discriminating between programs. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Exon vs base editing | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Delivery chassis | Identifies translational, regulatory, safety, or delivery constraints that shape whether the thesis can be tested. | Shows where the thesis could fail or require more validation before action. |
| Wash-out-is-a-feature home | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Common/metabolic disease | Summarizes a report component that ties field evidence to the dossier's decision logic. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Regulatory pathway | Explains which biological signals matter for interpreting the field and discriminating between programs. | Shows where the thesis could fail or require more validation before action. |
| Current signal: Wave WVE-006 | Frames the field's June 2026 state, active programs, research fronts, and timing signals. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Current signal: Beam BEAM-302 | Frames the field's June 2026 state, active programs, research fronts, and timing signals. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Evidentiary floor | Shows how strong the source base is and where conclusions depend on indirect or thinner support. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Quantitative Evidence | Links claims to source support so users can separate what is known, inferred, and hypothetical. | Lets the buyer audit support strength before relying on the package. |
| Mechanistic and Platform Deep Dive | Explains which biological signals matter for interpreting the field and discriminating between programs. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
| Adar Enzymology and Guide Chemistry | Explains which biological signals matter for interpreting the field and discriminating between programs. | Helps the buyer inspect the argument, evidence posture, and decision logic before relying on the package. |
Evidence & Decision Workbook
The workbook is the decision engine.
A locked public preview of selected workbook-derived sheets: sheet structure, decision modules, power rows, traceability, and audit posture. Licensed buyers receive the full workbook files.
Read-only workbook preview with clipped values and no formulas. Licensed buyers receive the full Evidence & Decision Workbook with editable assumptions and working files.
Workbook inventory
Delivered workbook sheets.
Full inventories belong on dossier pages, not the homepage. Sheet names below are extracted from the actual workbook file.
| # | Workbook sheet | What it does |
|---|---|---|
| 1 | 1. Workbook Guide | Navigation layer for using the workbook, understanding sheet roles, and following the decision package. Public preview exposes Point-in-time, June 2026 - evidence window. fields and clipped entries such as Source-audit reconciliation, 167 audited = 35. |
| 2 | 2. Claim Ledger | Claim-by-claim ledger showing verdicts, source support, inference status, and decision relevance. Public preview exposes claim_id, claim_text, report_section, report_page fields and clipped entries such as F1, AIRNA dosed the first patient in the., AATD. |
| 3 | 3. Evidence Table | Evidence-verification surface for checking sources, support quality, and the audit trail. Public preview exposes NCT:NCT06445322, Prescreening Study to Identify., ClinicalTrials.gov, 2024-06-20 fields and clipped entries such as NCT:NCT06467344, ACDN-01-001:. |
| 4 | 4. Source-Support Verdicts | Independent check on whether key claims are actually supported by cited sources. Public preview exposes claim_id, claim_text, source_support_verdict, perfect_audit_status fields and clipped entries such as F1, AIRNA dosed the first patient in the.,. |
| 5 | 5. Source-Quality Summary | Summary of source strength, gaps, and areas where conclusions depend on weaker evidence. Public preview exposes Audited claims, 167 = 35 kept + 132 excluded (116. fields and clipped entries such as Customer-facing findings, 52 (consolidated to 17., Fresh. |
| 6 | 6. Evidence-Maturity Matrix | Evidence-verification surface for checking sources, support quality, and the audit trail. Public preview exposes Cluster, Best evidence reached, Durability shown, Reversibility/redosing fields and clipped entries such as AATD - RNA edit (WVE-006/AIR-001),. |
| 7 | 7. Permanence-Spectrum Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes snRNA-enhanced RNA editing, (academic), ADAR base-editing (engineering), n/a fields and clipped entries such as Peptide-ionizable LNP, (academic),. |
| 8 | 8. Delivery-Chassis Tracker | Captures failure modes and constraints that could invalidate or narrow a program. Public preview exposes Program, Company, Chassis, Target tissue / indication fields and clipped entries such as WVE-006, Wave Life Sciences, GalNAc (subcutaneous). |
| 9 | 9. ADAR-Availability Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes Tissue, Endogenous ADAR availability, Ceiling / editability, Biology note fields and clipped entries such as Liver, High (ADAR1 ubiquitous +. |
| 10 | 10. Bystander-Specificity Track | Workbook surface supporting a specific evidence, decision, study-planning, or release-control workflow. Public preview exposes Off-target class, Mitigation, Persistence (vs DNA off-target), Evidence / note fields and clipped entries such as Proximal. |
| 11 | 11. Trial - Catalyst Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes NCT, Trial / asset, Sponsor, Indication fields and clipped entries such as NCT06405633, RestorAATion-2 (WVE-006), Wave. |
| 12 | 12. Company - Sponsor Tracker | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes Company, Lead asset(s), Indication(s), Disclosed capital / runway fields and clipped entries such as Wave Life Sciences, WVE-006 (ADAR/GalNAc), AATD. |
| 13 | 13. Safety - Risk Tracker | Captures failure modes and constraints that could invalidate or narrow a program. Public preview exposes Risk / failure mode, Mechanism, Mitigation, Severity (expert) fields and clipped entries such as Bystander A-to-I editing, off-target mis-editing of.,. |
| 14 | 14. Biomarker - Endpoint Tracke | Tracks biomarkers or readouts that determine whether the thesis is moving toward testable evidence. Public preview exposes Biomarker / endpoint, Type, Reported value (labelled), Limitation fields and clipped entries such as Total serum AAT (uM), surrogate. |
| 15 | 15. Regulatory Tracker | Tracks regulatory, endpoint, reimbursement, or qualification requirements that shape testing strategy. Public preview exposes Channel / item, Nature (named precisely), Applies to, Note fields and clipped entries such as IND / first-in-human, standard, all. |
| 16 | 16. Hypotheses Ledger | Maps hypotheses to evidence state, falsification logic, endpoints, and next-study design. Public preview exposes ID, Tier, Paradigm?, Axis / title fields and clipped entries such as F1, Flagship, PARADIGM. |
| 17 | 17. Most-Valuable Next Studies | Prioritizes next studies that could change the decision, including endpoints and evidence gates. Public preview exposes ID, Study, Research question, Primary readout fields and clipped entries such as MVNS-1, Delivery-controlled., Does renting beat owning. |
| 18 | 18. Validation-Falsification Ga | Connects proposed validation work to falsification criteria, readouts, and decision gates. Public preview exposes Each gate linked to a principle. fields from this sheet. |
| 19 | 19. Figure Source Map | Traceability surface linking claims, figures, calculations, and workbook outputs back to sources. Public preview exposes Fig #, figure_id, figure_title, figure_family fields and clipped entries such as fig04_decision_snapshot, Figure 1, central_thesis_model. |
| 20 | 20. Figure Attempt Ledger | Figure and numeric reproduction log for validating calculations, chart inputs, or displayed values. Public preview exposes figure_id, figure_family, data_type, attempted fields and clipped entries such as fig02_maturity_ladder, evidence_maturity_heat_map,. |
| 21 | 21. Verification & Search Log | Release-discipline surface for revisions, unresolved issues, audit findings, and readiness tracking. Public preview exposes #, API / source, Query or signal, Results fields and clipped entries such as ctgov, spons=Wave Life Sciences, build-search. |
| 22 | 22. Excluded Claims | Disposition log for rejected, bounded, or quarantined claims so they do not leak into the decision thesis. Public preview exposes Excluded 1 — In the., structural, (none), ungroundable fields and clipped entries such as Excluded 2 — A Phase 1, open-label,.,. |
| 23 | 23. Salvage Ledger | Disposition log for rejected, bounded, or quarantined claims so they do not leak into the decision thesis. Public preview exposes Recovered item, Recovered text, Recovered as, Source fields and clipped entries such as Excluded 1 — In the RestorAATion-2., In. |
| 24 | 24. Traceability Certificate | Traceability surface linking claims, figures, calculations, and workbook outputs back to sources. Public preview exposes claim_id, report_section, report_page, claim_text fields and clipped entries such as F1, AATD natural experiment / Half-life., section. |
| 25 | 25. Score Basis | Explains how scores or ratings were assigned so the decision instrument can be inspected. Public preview exposes Figure / ordinal, What is scored, Scale / anchor, Basis (verified source / logic) fields and clipped entries such as fig04 decision snapshot, GO. |
| 26 | 26. Power Calculations | Power-calculation layer for assumptions, endpoint logic, computed sample sizes, and sensitivity checks. Public preview exposes hypothesis_id, study_id, endpoint, test_type fields and clipped entries such as F1, MVNS-10, Predict PMC program traction.. |
| 27 | 27. Competitive Landscape | Tracks programs, trials, sponsors, or competitive context for diligence and monitoring. Public preview exposes company, asset, modality, target fields and clipped entries such as Wave Life Sciences, WVE-006, ADAR base-editing (AIMer). |
| 28 | 28. PMC Input Template | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes feature_id, rubric, demo_score, allowed_values fields and clipped entries such as F1 Half-life match, required correction half-life., 0,1,2,3. |
| 29 | 29. PMC Feature Score | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes F5 Mechanism reach fit, Col 2, input mirror fields and clipped entries such as F6 Bystander-specificity headroom, input mirror, F7. |
| 30 | 30. PMC Class Output | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Class Output: required PMC output. fields from this sheet. |
| 31 | 31. PMC Decision Rules | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes Class, Recommended., Required next experiment, Primary functional endpoint fields and clipped entries such as RENT-FITS-NOW, Run the RNA-editing. |
| 32 | 32. PMC Archetype Cards | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes archetype, input_vector_F1_to_F7, dominant_class, top_raw_class fields and clipped entries such as AATD RNA/GalNAc, 0,1,3,3,3,2,0,. |
| 33 | 33. PMC Minimum Assay Panel | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes panel_item, assay/data_source, measurement, classifier_feature fields and clipped entries such as Half-life requirement, disease biology/natural. |
| 34 | 34. PMC Validation Log | Executable decision surface for classifying programs, risks, gates, or evidence states. Public preview exposes heldout_program, WVE-006 / RestorAATion-2 AATD, 0,1,3,3,3,2,0, HALF-LIFE-MISMATCHED fields and clipped entries such as heldout_program, AIR-001. |
| 35 | 35. PMC Traceability Map | Traceability surface linking claims, figures, calculations, and workbook outputs back to sources. Public preview exposes feature, thesis_basis, report_surface, claim_ids fields and clipped entries such as F1, Half-life bifurcation, fig07; hypotheses F1/F5;. |
| 36 | 36. Version Registry | Release-discipline surface for revisions, unresolved issues, audit findings, and readiness tracking. Public preview exposes Rev-4, 2026-06-16, Perfect-audit remediation: DOI., Codex fields and clipped entries such as Manifest, Rev-4 perfect-audit. |
| 37 | 38. Evidence Maturity Watchlist | Evidence-verification surface for checking sources, support quality, and the audit trail. Public preview exposes evidence_gap, programs_or_claims, current_best_available_evidence, current_language_control fields and clipped entries such as Durability,. |
| 38 | 37. Audit Issues Log | Release-discipline surface for revisions, unresolved issues, audit findings, and readiness tracking. Public preview exposes issue_id, audit_finding, status, closure_detail fields and clipped entries such as MF-1, Figure count contradiction and., CLOSED. |
| 39 | 39. Currentness Refresh Triggers | Monitoring surface for emerging signals, update triggers, and evidence changes that could alter the decision. Public preview exposes program, pending_signal, expected_window, primary_source_to_monitor fields and clipped entries such as Wave WVE-006, 600 mg. |
Power-calculated next studies
Power calculations are the execution bridge.
Power calculations are planning-grade research calculations for endpoint logic, assumptions, sample size, budget, and timeline. They do not prove hypotheses or constitute clinical protocol.
| Hypothesis | Primary endpoint | Test | Effect | α | Power | Computed n | Design n |
|---|---|---|---|---|---|---|---|
| F1 | Predict PMC program traction (held-out) | AUC (Hanley-McNeil, live) | 0.8 | 0.05 | 0.80 | 88 | 90 |
| F2 | Functional M-AAT restoration by chassis | two-sample means | 1.3 | 0.05 | 0.80 | 10 | 24 |
| F3 | Editing durability half-life by chassis | two-sample means | 1.3 | 0.05 | 0.80 | 10 | 20 |
| F4 | Return-to-baseline on withdrawal | paired/within-subject | 0.9 | 0.05 | 0.90 | 13 | 24 |
| F5 | Integrated time-above-threshold interval | two-sample means | 1.3 | 0.05 | 0.80 | 10 | 20 |
Release audit discipline
Audit posture is part of the product.
Public pages do not publish exact audit scores. They should state the release discipline, revision posture, and limitations without implying peer review or validated clinical guidance.
Research-use decision package
Not medical advice, clinical guidance, investment advice, or a clinical protocol.
Known / inferred / hypothetical
The package separates cited evidence from inference and frontier hypothesis generation.
Audit-gated and revision-controlled
Adversarial audit checks source support, formulas, figures, limitations, and release readiness.
Buy this dossier
Full decision package — 112-page report + 39-sheet workbook
Buy now
- Decision research report (112 pages, PDF)
- Evidence & Decision Workbook (39 sheets, .xlsx) — claims, source-support verdicts, power calculations, traceability, and audit log
- Live, editable power-calculated next studies
$3,500$5,500Launch price